肿瘤微环境调控纳米药物   0703J1M05002H

学期:2020—2021学年(春)第二学期 | 课程属性:专业普及课 | 任课教师:聂广军,王婧,李素萍
授课时间: 星期五,第2、3、4 节
授课地点: 教一楼230
授课周次: 3、4、5、6、7、8、9、10、11、12、13、14
课程编号: 0703J1M05002H 课时: 36 学分: 2.00
课程属性: 专业普及课 主讲教师:聂广军,王婧,李素萍 助教:
英文名称: Cancer Nanotechnology 召集人:

教学目的、要求

Malignant tumors remain a major health burden throughout the world and new strategies are urgently needed to treat them effectively. Cancer nanotechnology has the potential to dramatically improve current approaches to cancer detection, diagnosis, imaging, and therapy while reducing toxicity associated with traditional cancer therapy. The application of nanotechnology to developing safer and more effective antitumor nanomedicine have so far proven to be both evolutionary and revolutionary and will eventually revolutionize the current landscape of cancer therapy.  

The multidisciplinary nature of nanomedicine requires integration of cancer biology, clinical oncology, chemistry, physics, materials science, biomedical engineering, toxicology, computer science, and mathematics to achieve the vital goals of nanotechnology-mediated early cancer detection and more efficacious and less toxic therapies for cancer. In this course, the fundamental sciences related to cancer nanotechnology in both cancer biology and nanoscience and technology will be covered. The issues related to preclinical and clinical applications of nanotechnology for cancer diagnosis and therapy will also be discussed. Some key methodological approaches in cancer nanotechnology and subject will also be outlined. This course will be helpful for graduate students to get an overall picture about the current landscape of nanotechnology integrated into the current tumor biology and clinical oncology.  

预修课程

教 材

Among the several books on the list of cancer nanotechnology, there are a few books with different focuses. For a general understanding of the cancer nanotechnology, the book “Nanotechnology and Oncology: Workshop Summary” is available. If you have great interest in this area Cancer Nanotechnology: Nanomaterials for Cancer Diagnosis and Therapy is recommended. However, if you are going to do your own research on the cancer nanotechnology, the “Cancer Nanotechnology: Methods and Protocols” will be helpful to provide some hands experience.  

主要内容

Session one: Fundamentals of Cancer Nanotechnology 

1. Introduction of the course  

2. Cancer Biology: fundamental cancer biology and the recent progress on tumor cells and their microenvironment will be introduced.  

3. Clinical Oncology: clinical pictures of major malignant tumors (including breast cancer, pancreatic cancer and liver cancer etc) and the major therapeutic strategies will be covered. The major challenges of current clinical treatment of cancer will also be discussed.   

4. Preclinical and clinical antitumor drug development.  

5. Cancer nanotechnology: when cancer biology and medicine meet nanotechnology, some unique biochemical and physiological mechanisms of cancer biology will be applied to tumor therapy and diagnosis, such as passive and active targeting and co-delivery strategy. Some new nanoscale mechanisms of cellular functions relevant to cancer will be discussed.  

6. Issues of Nanotoxicity in antitumor drug discovery: one of major barriers to overcome for developing nanomedicine is the nanotoxic issues related with the nanomaterials. Some fundamental concepts of nanotoxicology will be covered in this chapter.  


Session two: Nanomaterials for Cancer therapy and Diagnosis 

7: Why nanomaterial platforms will be good for cancer therapy and imaging? Overview of the major progress of nanotechnology for cancer diagnosis and therapy and major nanomaterials using and developing for nanomedicine will be discussed.   

8. Polymeric nanoparticle system for cancer therapy and diagnosis.    

9. Inorganic nanomaterials for cancer therapy and diagnosis. 

10. Biomolecules-based nanoparticles for cancer therapy and diagnosis. 

11. Hybrid nanomaterials for cancer therapy and diagnosis. 


Session three: Recent Progress and invited talks 

Recent progress on cancer biology, clinical oncology and invited lectures will be delivered by world-renowned academic and industrial researchers based on the availability of time and speakers.   


Expected level of proficiency from students entering the course: 

Biology: highly recommended 

Biomaterials: recommended 

Chemistry: recommended 

参考文献

There are large numbers of review papers in this emerging field. At the first step, the three review papers will be good to have a general concept about the field. 

1. Jones, D. (2007). "Cancer nanotechnology: small, but heading for the big time." Nature Reviews Drug Discovery 6(3): 174-175. 

2. Ferrari, M. (2005). "Cancer nanotechnology: Opportunities and challenges." Nature Reviews Cancer 5(3): 161-171. 

3. Service, R. F. (2005). "Nanotechnology takes aim at cancer." Science 310(5751): 1132-1134. 

4. Ji, T.J. et al (2013). Using nanotechnology to target and regulate the tumor microenvironment: diagnostic and therapeutic applications, Advanced Materials, 2013; 25: 3508-25. 

5. 丁艳萍,季天骄,聂广军,纳米技术识别和调控肿瘤微环境用于肿瘤诊疗的研究进展, 科学通报, 2013, 58, 2436-2448 (in Chinese). 


Next, you can read some paper discussing the recent progress about cancer nanotechnology. 

1. Banerjee, H. N. and M. Verma (2008). "Application of nanotechnology in cancer." Technology in Cancer Research & Treatment 7(2): 149-154. 

2. Majoros, I. J., B. B. Ward, et al. (2010). "Progress in Cancer Nanotechnology." Progress in Molecular Biology and Translational Science, Vol 95 95: 193-236. 

3. Peer, D., J. M. Karp, et al. (2007). "Nanocarriers as an emerging platform for cancer therapy." Nature Nanotechnology 2(12): 751-760. 

4. Schroeder, A., D. A. Heller, et al. (2012). "Treating metastatic cancer with nanotechnology." Nature Reviews Cancer 12(1): 39-50.